| #832 | Tic-Tac-Toe | Dec 10, 2010 |
| #831 | Weather Radar | Dec 8, 2010 |
| #830 | Genetic Analysis | Dec 6, 2010 |
| #829 | Arsenic-Based Life | Dec 3, 2010 |
| #828 | Positive Attitude | Dec 1, 2010 |
| #827 | My Business Idea | Nov 29, 2010 |
| #826 | Guest Week: Zach Weiner (SMBC) | Nov 26, 2010 |
| #825 | Guest Week: Jeffrey Rowland (Overcompensating) | Nov 25, 2010 |
| #824 | Guest Week: Bill Amend (FoxTrot) | Nov 24, 2010 |
| #823 | Guest Week: David Troupes (Buttercup Festival) | Nov 23, 2010 |
| #822 | Guest Week: Jeph Jacques (Questionable Content) | Nov 22, 2010 |
| #821 | Five-Minute Comics: Part 3 | Nov 19, 2010 |
| #820 | Five-Minute Comics: Part 2 | Nov 17, 2010 |
| #819 | Five-Minute Comics: Part 1 | Nov 15, 2010 |
| #818 | Illness | Nov 12, 2010 |
| #817 | Mutual | Nov 10, 2010 |
| #816 | Applied Math | Nov 8, 2010 |
| #815 | Mu | Nov 5, 2010 |
| #814 | Diode | Nov 3, 2010 |
| #813 | One-Liners | Nov 1, 2010 |
| #812 | Glass | Oct 29, 2010 |
| #811 | Starlight | Oct 27, 2010 |
| #810 | Constructive | Oct 25, 2010 |
| #809 | Los Alamos | Oct 22, 2010 |
| #808 | The Economic Argument | Oct 20, 2010 |
| #807 | Connected | Oct 18, 2010 |
| #806 | Tech Support | Oct 15, 2010 |
| #805 | Paradise City | Oct 13, 2010 |
| #804 | Pumpkin Carving | Oct 11, 2010 |
| #803 | Airfoil | Oct 8, 2010 |
| #802 | Online Communities 2 | Oct 6, 2010 |
| #801 | Golden Hammer | Oct 4, 2010 |
| #800 | Beautiful Dream | Oct 1, 2010 |
| #799 | Stephen Hawking | Sep 29, 2010 |
| #798 | Adjectives | Sep 27, 2010 |
| #797 | debian-main | Sep 24, 2010 |
| #796 | Bad Ex | Sep 22, 2010 |
| #795 | Conditional Risk | Sep 20, 2010 |
| #794 | Inside Joke | Sep 17, 2010 |
| #793 | Physicists | Sep 15, 2010 |
| #792 | Password Reuse | Sep 13, 2010 |
| #791 | Leaving | Sep 10, 2010 |
| #790 | Control | Sep 8, 2010 |
| #789 | Showdown | Sep 6, 2010 |
| #788 | The Carriage | Sep 3, 2010 |
| #787 | Orbiter | Sep 1, 2010 |
| #786 | Exoplanets | Aug 30, 2010 |
| #785 | Open Mic Night | Aug 27, 2010 |
| #784 | Falling Asleep | Aug 25, 2010 |
| #783 | I Don't Want Directions | Aug 23, 2010 |